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It depends on the course, its competitiveness and the quality of the other applicants. Normally, we would say that the information on university websites regarding minimum entrance requirements should be treated as an absolute minimum. However, universities will look at the whole application including GCSE and AS results, so it is difficult to second guess decisions.
There is nothing to stop your son applying. But given that his predictions are lower than the usual requirements he should be realistic about receiving some rejections. It's important, therefore, that his UCAS choices include some universities that are likely to make him an offer.
I'm not sure which course or which universities you are looking at, so I hope this helps!