Ocular Oncology MD

Overview

Professor Sarah Coupland is a Lead of the Liverpool Ocular Oncology Research Group (LOORG), Professor Sarah Coupland is a Consultant Histopathologist and the George Holt Chair of Pathology, University of Liverpool. She is also the Director of the North West Cancer Research Centre-University of Liverpool. The group focuses clinical on molecular genetics of cancers with particular interests in uveal melanoma; conjunctival melanoma; intraocular and ocular adnexal lymphomas.

Research themes

ITEM: CR-UK funded multicentre single arm phase II study of imatinib in good performance status patients with c-kit positive metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

SUAVE: CR-UK funded multicentre randomised phase II study of sunitinib in good performance status patients with metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

Our research themes include:

Uveal melanoma
Conjunctival melanoma
Intraocular and ocular adnexal lymphomas
CNS lymphoma.

Our reserach interests include:

The role of tumour stem cells in uveal melanoma development and progression
Identification of regulators of metastasis
Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets
Comparative digital transcriptional profiling of canine and human uveal melanomas
Proteomic discovery of serum biomarkers in metastatic UM
The role of a novel inhibitory isoform of VEGF in ocular melanoma
Conjunctival melanoma: a multicentre study correlating baseline features with histology and genetics
Gross chromosomal abnormalities in iris melanoma
Estimating survival prognosis after treatment of choroidal melanomaMedical education.