Ocular Oncology MD

University of Liverpool

The University has invested over £20 million in cancer research which has been used for the creation of several new posts in the Department, and in the establishment of the University of Liverpool Cancer Research Centre (ULCRC) building.

Overview

Professor Sarah Coupland is a Lead of the Liverpool Ocular Oncology Research Group (LOORG), Professor Sarah Coupland is a Consultant Histopathologist and the George Holt Chair of Pathology, University of Liverpool. She is also the Director of the North West Cancer Research Centre-University of Liverpool. The group focuses clinical on molecular genetics of cancers with particular interests in uveal melanoma; conjunctival melanoma; intraocular and ocular adnexal lymphomas.

Research themes

ITEM: CR-UK funded multicentre single arm phase II study of imatinib in good performance status patients with c-kit positive metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

SUAVE: CR-UK funded multicentre randomised phase II study of sunitinib in good performance status patients with metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

Our research themes include:

• Uveal melanoma
• Conjunctival melanoma
• Intraocular and ocular adnexal lymphomas
• CNS lymphoma.

Our reserach interests include:

• The role of tumour stem cells in uveal melanoma development and progression
• Identification of regulators of metastasis
• Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets.